Top Definition
When you have a terrible case of diarrhea and it sounds like someone is deflating a wet balloon the size of the Hindenberg.

"Oh my sack! I've just had the maddest case of the screamers!!

"Tom had the screamers so bad i could hear him from next door."

"Dude, i just gave birth to the antichrist! savage case of the screamers!"
by PinkyDrew June 11, 2008

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