Top Definition
A gene that when injected into your bloodstream gives you the appearance of being funny even though you've said nothing funny
You: So what's this one?
Doctor: The Seth Rogen gene, it gives you the appearance of being funny even though you've said nothing funny.
You: Oh... Hey doc are we done here? I gotta grab some beers with the fellas.
Doctor: HAHAHA! THAT IS HILARIOUS!
by BigJ91 May 25, 2011

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