Top Definition
When a female friend becomes sexually attractive, virtually out of nowhere, reminiscent of Elliot Reid from the hit TV show Scrubs.
Brian: Oh man, Jessica turned me on so hard last night! It was freaking out of nowhere man!
Max: Yeah dude, same thing happened with Mel the other week, totally played The Scrubs Effect on me.
by iamthemaddog June 08, 2011

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