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1.
A very harsh case of diarrhea where one will sit on a toilet for an extended period of time while what feels like flames shoot out of one's rectum, esp. after eating exceptionally spicy food.
Dude 1: Where's Steve, I haven't seen him since yesterday.

Dude 2: He's probably sitting on the john with a case of The Screamin' Meanies.
by sean82fta July 26, 2005

Words related to The Screamin' Meanies

aztec two step diarrhea hershey squirts john squirts the runs the shits
 
2.
Diarrhea, particularly after eating spicy food.
I have The Screamin' Meanies from that cabrito last night.
by Dylan Howard October 19, 2005