A very harsh case of diarrhea where one will sit on a toilet for an extended period of time while what feels like flames shoot out of one's rectum, esp. after eating exceptionally spicy food.
Dude 1: Where's Steve, I haven't seen him since yesterday.

Dude 2: He's probably sitting on the john with a case of The Screamin' Meanies.
by sean82fta July 26, 2005
7 Words related to The Screamin' Meanies
Diarrhea, particularly after eating spicy food.
I have The Screamin' Meanies from that cabrito last night.
by Dylan Howard October 19, 2005

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