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1.
A mysterious sequence of numbers that keeps appearing, either in fully or individually, on the American hit TV drama Lost. The sequence is 4-8-15-16-23-42.
"Wait, that metronome has '108' on it! Isn't that the sum of the Numbers?"
by Shay Guy October 23, 2006
 
2.
The best. A phrase used when an act, object or person produces 1. positive financial return; 2. positive outcome; 3. when situations occur allowing for gain
Example 1.
"I don't know how to tell you this, but I'm kind of a big deal. You could say I'm the numbers of Napa Valley."

Example 2.
"We finished 10 surgeries by 5pm! That's the numbers!"
(The surgeon completed a large number of cases in a short amount of time, thus leading to an increase in profit for the hospital and surgeon. The numbers.)
by Pistol Layman August 28, 2011
 
3.
Uptown Manhattan, where numbers are used to define streets, not names. Everything above 14th street, more or less. Meaningless jive area, doesn't need to exist.

Everything except New A-Town in Manhattan is "The Numbers"
Guy one: I ain't goin all the way to fourty-deuce, I am staying away from the numbers.

Guy two: Word, screw them. New A-Town pride!
by atomic jerk December 21, 2005