Top definition
A television channel featuring programming targeted to appeal to middle-class, white, suburban, middle-aged women. Lifetime was the original Estrogen Channel. Now competing for estrogen with WE and Oxygen.
Hey, there's another Sandra Bullock movie on the Estrogen Channel tonight, and after that they're showing "Hope: One Woman's Struggle with Breast Cancer" starring Melissa Gilbert and Peter Gallagher.
by wakawakawaka April 20, 2008
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