look up any word, like swag:
 
4.
the best big brother ever even though he is also the biggest a-hole in the world...it is out of love...Also another way to differentiate between a Sr. Dad and a Jr. Son
Brain Sr. = The Big One
by Bubba69420 January 27, 2009
 
1.
What one bites when one dies.
That dude is totally dead, he bit the big one.
by jcoffland May 09, 2010
 
2.
A phrase used in NASCAR to describe a large crash at Daytona, or Talledega involving several cars. Usually caused by the restrictor plates on the cars keeping them bunched together, 3 or 4 across, 43 deep, untill one car in the front cuts down in front of another car to close, and spins out in front of the rest of the pack. The Big One usually has 5-10 cars involved but some have had up to 26.
Just look up "The Big One @ Daytona" and you will get a pretty good idea.
by Gamewizard September 30, 2009
 
3.
It's the one people always talk about, the mythical/legendary big one. why isn't it already defined?
Refers to anything big, a big piece of food, a big sex organ, a big butt, or anything else that is big.
Hah! He bit the big one!
by wichita March 16, 2008