The unfortunate result that occurs after incest, sexual harassment, or intimate relationships are ended between closely-related family members, destroying all holiday spirit, hence the name Thanksgiving Syndrome, because of the dread of seeing that special someone at the dinner table again for the holidays, which would inevitably relive the once pleasureable or even forced orgasms that secretly occurred with that someone.
John: Why does your sister look so depressed when tomorrow is Christmas?
Mark: She has the Thanksgiving Syndrome.
John: The what?
Mark: Our cousin fucking raped her last month, and the unconvicted son of a bitch is going to be at our Christmas dinner tomorrow.
by Kevin Lao March 05, 2006
Top Definition
The result of binge-eating holiday food, much like what many people do on Thanksgiving Dinner.

Characterized by a horrible sick and overstuffed feeling, sometimes followed by the urge to throw up as you lay sprawled out on the couch desperately trying to feel better.

Yeah, you know you shouldn't have eaten that last piece of pie, but damn... it was soo good!
"Arrghhhuhhhhhgrrrggg I'm dyinggggg..."

"Dude, what's wrong?"

"Uhhhhhhhrrggg... I ate to much _insert holiday here_ food and now my stomach's killing me..."

"Yikes, looks like you've got Thanksgiving Syndrome bad."

"Ughhh... I'm NEVER going to eat again..."
by Tennisgurl95 April 23, 2011
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