1.A phrase spoken in sarcastic response to an exclamation or question that could claim no basis in the conversation at hand. 2. A sarcastic phrase spoken in response to a statement made in regards to nothing and usually not following any discernible thought pattern.
This phrase is generally thought to refer to a person "George" who is slow or dim witted and is therefore continually dismissed with a "Thank you" for his worthless contribution. The phrase also carries undertones of an allusion to the work Of Mice and Men which, though George in this case is the smarter of the two, conjures up images of severe learning disability or mental retardation. In any event, the phrase is meant to imply that the person is below average intelligence and what they said is to be dismissed or explained in further detail depending upon the tone with which it was spoken.
John: I think the Beatles are the greatest band of all time.
Joe: I think they could have benefited from a more improvisational influence.
John: An improvisational influence? They had a revolutionary sound and needed no further improvement. Making the Beatles a Jam Band would have ruined everything.
James: Did you guys ever notice that cotton candy is dry, but still sticky?
(Joe and John exchange a glance)
Joe: Thanks George...
(John and James are riding in a car silently and have been so for some time)
James: You know, I really like the smell of basketballs.
John: Thanks George...you moron.