To eleminate someone. To kill him. To remove someone from a situation.
"Osama bin Laden is a menace. We will take him out." President George W Bush.
by Colby Gutierrez-Kraybill August 24, 2005
1 more definition
The act of Roasting, Jonin', or insulting someone (usually in front of a group of people) until they can't say anything back
"oo wee im about to take him out with them nasty ass walmart jeans on"
by fye boy November 22, 2009