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"Take a Midol" is a disparaging phrase said to a woman who is behaving in a bitchy and confrontational fashion, as women are know to do when experiencing the symptoms of PMS. Sometimes said by a male, the phrase is more powerful when uttered by a female toward another female, as a strong complaint about the woman's behavior and/or attitude. (Midol is a commonly used over-the-counter medication marketed to women for the symptoms of PMS.)
Woman to woman: What is wrong with you? Stop being so upset and take a Midol!

Man to woman: Honey, please! Take a Midol before we have another domestic violence event in this house trailer!
by Rook's Buddy June 02, 2010
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