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3.
That had to hurt; a way to respond after hearing or saying something funny, mean, etc.
Jack: Congratulations! How far along are you?
Jill: What are you talking about? I'm not pregnant.
Jack: Oh. THTH.
by Jolie85 December 03, 2007
 
1.
means "To Hot to Handle"
taken from Danny Noriega's "TMTH"
Danny Noriega and David Archuleta are definatly THTH!
by XOXPIRATENINJAXOX July 12, 2008
 
2.
Too horny to handle.
You are THTH!
by Carolyn May 08, 2004