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2.
1. The Fuck Is Up
2. The act of frustration towards a situation, which one does not clearly understand.
Guy 1: (Walks in on girlfriend sleeping with best friend)
Guy 1: TFIU!
Guy 2: Umm....
by Matteo Ivan July 28, 2011
 
1.
1. The Future is Useless!
2. When there is no hope left.
Guy 1: Hey, did you apply for college?
Guy 2: Nope, TFiU!
by Jack Minor April 09, 2008