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1.
Acronym for Too Fat To Masturbate, a horrifying condition in which a person is too fat and disgusting to get themselves off.
When you have to dip yourself in flour first, you're TFTM
by GrammerCat January 09, 2009
 
2.
Acronym for Thanks For The Memories, rapidly becoming an internet colloquialism. It's generally appended to a winning remark to enhance a user's satisfaction upon victory over a situation.

The phrase is also a play on the Fall Out Boy single "Thnks Fr Th Mmrs".
AkiraBoss: you only won cause i have a noob team and bad lag
AkiraBoss: wanna 1v1 and i'll show you who's noob?
modestdude: gg tftm

JellyBurger: i'm not a feeder if my score is 3-12
AnyoneWithABrain: rofl gg tftm
by Zhe Wang July 26, 2007