The act of becoming completely intoxicated beyond human control, helplessly inebriated. Its one step beyond plastered, sauced, bombed, wasted, etc.
Lets start drinking early so we can get suissed up before getting to the bar.
The act of being under the influence of any state alterign substance. Most often used specifically for low grade Mexican street heroin.
T.O. was so suissed up after doing those skin poppers that he tried to make out with a dude on the way to the hospital.