The pills (and god forsaken sublingual strips) contain 8mg of buprenorphine. A typical (insuflated) recreational dose for someone who doesn't otherwise use opiates is 2 milligrams, simply referred to as "a quarter", because it's a quarter of the pill/strip. First time users should begin with 1mg, or "an eighth".
Suboxone doesn't need to be insuflated, although it is most common among recreational users. Taking it orally/sublingually, as medically intended, does not yield great results as the bioavailibility with these routes of administration are very low.
Shooting it yields the best results. Despite people saying that Naloxone (present in Suboxone) prevents people from administering it intravenously, it works best. Only an eighth is needed to get high, even for fairly tolerant users, and effects are felt in as little as ten minutes.
Always begin with an eighth of a sub when trying it for the first time, and take Dramamine or Benadryl with it, as the high is unusually long and can cause nausea.
Always use sterile rigs when shooting up, and don't share.
"I'd better not drink too much tonight, I just hit the sub."
"Bummer, Andrew's parents cut off his Suboxone prescription."
The active substance, buprenorphine, has effects at the mu opiate receptor that are different than effects of pain pills or methadone. Oxycodone, methadone, and hydrocodone are all 'agonists', meaning that the more drug, the more effect at the receptor. Naloxone and Naltrexone are mu 'antagonists'-- they will block the effects of pain pills and have no stimulating effect at the receptor. Buprenorphine is a 'partial agonist'-- in between the two. It will activate the mu receptor and relieve pain up to a certain point, where it has a 'ceiling' to it's effect. Beyond that point, any increases in dose of buprenorphine will have no extra effect. Buprenorphine becomes an 'antagonist' at that point, blocking the receptor so that any other opiate medications will be ineffective.
The result is that treatment with buprenorphine virtually eliminates cravings for opiates in opiate addicts who use it properly. It can be taken once per day, and will also block the effects of any other opiates the addict may take. Because of these effects, buprenorphine is considered a 'remission agent'-- it will induce remission of opiate addiction, but it is NOT a cure. When an addict stops buprenorphine, all of the prior features of his/her addiction will return if the addict does not do something to replace the buprenorphine-- such as become involved in 12 step groups.
While not a cure, there is no truth to the oft-heard comment that buprenorphine is only 'replacing one drug with another'. Opiate addiction consists of the obsession for opiates; the addict's mind is taken over by the singular concern for finding the next dose. Buprenorphine effectively treats addiction by eliminating the obsession far beyond what occurs with taking an opiate agonist.
More and more addictionologists are recognizing that buprenorphine and Suboxone should be considered long term treatments.
If you take Suboxone too soon after an opiate, you will go into withdrawal. If you take an opiate too soon after Bupe, the bupe will block the effects and you won't get high.
"Got and stop signs" = Do you have any suboxone?
The naloxone is supposed to be a blocking agent to deter use from IV, but in all reality the addition of naloxone was a marketing ploy to get it scheduled lower and thus be easier prescribed. The buprenorphine itself binds much higher to the opioid receptors, even higher than the naloxone. The claim that suboxone does not work when injected is not real....but if you're trying to get clean ( and given suboxone's cost and hassle to go find a doctor and deal with him ) what's the use of injecting it, you're just perpetuating the same behavior and might as well just go score a full agonist with more euphoria to inject.
A friend gave me a suboxone and i threw up all day long