Phrase used when you and your friends are high as fuck and one friend is laughing uncontrollably at something.

Is usually said in a high pitched patronizing way to make the person struggle even harder.
Fred: PINEAPPLE HAHAHA AAAHAHAHAHAHA

Jim: STRUGGLE BUS!

John: STRUUUUGLE BUUUUS!!!

Fred: BAAHAHAHA *Gasp* XD PFFTNNHAHAHAHAHAHAHA
by Not a real letter November 24, 2008
Having to deal with a difficult relationship or having to go out of your way in order please somebody like your significant other or boss.
"It is nice to just have a normal relationship with someone instead of getting a hard time from them every time you ask them to do something for you. It's like everything you do with them is a struggle all of the darned time. Thank God I am off of THAT STRUGGLE BUS!!!!
by Profound Wisdom March 07, 2016

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