to drive a stickshift usually means to give a handjob, but it can mean pretty much anything involving a penis, as the term is fairly general. Since it's fairly new, most people fall for it and think your asking about a car when you ask "Do you know how to drive Stickshift?"
"Yeah I've driven Tom's"
"Oh your dirty..."
Eric: Well, I drive a stickshift if that matters.
Joe: Oh, okay. I don't know how to drive one.
Eric: Sorry buddy, I can't help you there.