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2.
Hot and spicy food that burns first in the mouth, and burns a second time in the act of defecation.
You should be careful: that Thai Chili Stirfry is no doubt spicy twicey.

1: What's all that screaming from the bathroom?
2: It's Chuck, in pain from his spicy twicey flamethrower burger from last night.
by Neologist-PJG February 20, 2012
 
1.
When you consume a spicy snack, treat or meal... Then feel the spicy again later as you sit on the toilet.
That Louisiana Hot Link was AMAZING, but boy was it spicy twicey!
by AtrontheMAP May 11, 2011