Top Definition
after buying a new pair of Sperry Topsiders, and getting blisters, or rubbing your feet raw. Another type of Sperry syndrome is the rank odor of the feet caused from sockless wear.
"OUCH! My ankles have blisters all over them, I hate my Sperry's."
"Looks like a case of Sperry syndrome"
by PiePerView October 06, 2013

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