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1.
When someone is having WAY to much fun in spandex.
"Man, look at that guy, serious case of Spandexcstacy there."
by DeDoiche March 31, 2006
 
2.
When you get your jollies from wearing spandex.

A Mix of spandex and ecstacy.
"That guy dancer has a serious case of spandexcstacy"
by DeDoiche March 30, 2006