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4.
1. When used to describe something crazy or out of the ordinary.

2. When you use it to describe another person's actions. Oh no she didn't!
ex1. Connie: "I saw this homeless person dancing with a streetlamp yesterday."
Chase: "That is oh so sour."

ex2. Derek: "You're a dirty whore."
Lauren: "Oh no you sick and souuur!"
by ralucawashur July 28, 2009
 
1.
strongest type of weed
yooo i smoked od sour last night
by joed@hoe March 25, 2010
 
2.
to be upset, mad, or angry
whyd u bone my sister... now im sour
by Jason January 05, 2005
 
3.
an adjective used to describe someone who is visually disturbing, ugly, and/or nasty.
origin: at the site of a "sour" person, you make a "sour" face, as such when you suck a lemon.
Man, its pretty sour up in this club tonite.

Oh snap. DW's lookin pretty sour as usual.
by Wilred July 23, 2006
 
5.
1. opposite of sweet
2. A evil/angry/mad/nasty person
3. A Bitch
1. Bitter
2. What the fuck is wrong with that nigga?
3. Man, you acting hella sour today...
by Lazyie July 24, 2008
 
6.
The act of alienating and or disheveling others to better oneself. There are many ways to go sour, including: acting a fool in front of the opposite sex, blatant disregard for your friends' feelings, and flagrant self-centerdness.
Oh man, John is going sour tonight. Yeah, I can't believe he cock blocked you like that.
by Brian August 25, 2005
 
7.
The opposite of "sweeeet". Usually used to make the other person thinking about how stupid it is to say "sweet" all the time.
Person 1: Man those shoes are sweeeettt.
Person 2: Sour.

Person 1 left thinking how stupid he is for using the word sweet in that way.
by KKL May 29, 2006