Top Definition
is when the sophomores in high school start to feel more comfortable with high school because they're not freshmen anymore and start hooking up with anyone to fulfill their sexual appetites.

This can apply to anyone who's not a sophomore but still feels the need to get some all the time.
That Sophomore girl just decided to hook up with all of these guys for no reason..." "Sounds like she has Sophomore Syndrome.
by crazytruth135 November 01, 2010

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