Top Definition
1. A district of central London.

2. (SoHo) A district of southwest Manhattan, New York City. South of Houston Street, hence SoHo.
I woke up in a Soho doorway. A policeman knew my name. He said, "You can go sleep at home tonight if you can get up and walk away."
by Wang Chung January 17, 2004

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The area of Manhattan between Houston&Canal, and Bowery&6th Ave. While not very large, Soho has become the definition of what most people think of when they think of Manhattan. Countless upscale/overpriced stores, delis where a sandwich costs more than a steak, and coffee houses far and wide. The number one tourist attraction despite its conplete lack of historical and personal value. While it keeps Manhattans economy booming is exactly what will keep the rich getting richer and the poor getting poorer. Has succeeded in destroying the City from the inside.
Jeff: Hey man, we're all goin' out Soho to get some 12 dollar sandwiches and then we'll hit up Starbucks for some 7 dollar coffee.

Dave:(single tear drips from his eye)
by Clover G April 01, 2006

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In Manhattan, New York City, New York, Soho is the area just South of Houston Street.
I just got this kickin apartment in Soho!
by David Maurio May 17, 2004

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Small office, Home office.
Term commonly used when talking about smaller computer networks.
I got some mad 1GBit pipes in my soho lan man!
by tewm June 11, 2005

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short for South of Houston Street. Located in Manhattan but extremely hard to designate a specific startpoint and endpoint as it is constantly changing and growing. Currently Manhattan's Largest Mall. Historically known as an artists haven, most have fled to Williamsburg, Brooklyn
On my last trip to New York city, I went to Times Square, The Empire State Building, Little Italy and Soho.
by ritechus September 11, 2005

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An area in the centre of the West End of London, England, in the City of Westminster. It is an area of approximately one square mile bounded by Oxford Street to the north, Regent Street to the west, Shaftesbury Avenue to the south and Charing Cross Road to the east. Formerly known as Londons Red light District and famous for it's sex shops but now more famous for it's restaurants and clubs.
The college students decided on a night out in soho at their favourite restaurant
by Big Dave 999 January 24, 2008

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City inspired fashion, not trendy however uniquely artistic in the manner of style.
1. I love your hat, it's so SoHo.
by ja-nine February 20, 2010

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