A suitcase nuke that fits inside a woman's snizz or snatch. It is short for either "snatch nuke" or "snizz nuke". The term was first used in the South Park episode "The Snuke". The snuke was located in Hillary Clinton's vagina.
CIA Agent: "Hillary Clinton has a suitcase nuke in her sniz."
Cartman: "A snuke?"
CIA Agent: "Yeah."