2. It can also be used with a modifyier "snakes on a mother fucking plane"
Bob:Yeah it was so snakes on a plane!
2. Joe:Did you see that awesome jump?
Bob:That was so snakes on a mother fucking plane
The word "snakes" can be substituted with almost anything, and the word "plane" can be any place or vehicle or large-enough object.
The prepositional phrase "on a" may be substituted if necessary, but should normally remain the only constant, as the "animal ON A place/vehicle/object" grammatical structure is what references the movie and indicates the absurdity of the problem.
Ant-infested bathroom = "Ants on a Bathroom."
Tarantula attacks someone on a dorm hall stairway = "Spiders on a Staircase"
A garbage can or recycling bin unauthorized for such purposes nevertheless contains bio-hazardous material = "Germs on a Trash Can"
Someone's attic proves to be a breeding ground for an army of houseflies = "Flies on an Attic"