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22.
To severely shame and humiliate an individual in a verbal confrontation or direct insult; A powerful cut down (usually very clever or rooted in an opponents weakness); Would initiate a response from a crowd such as "dayuummm bruh!".

"Ohh sheeit bruh, that dude juss slayed his bitch ass"
by Purple Lean King April 02, 2007
84 118
 
1.
to mercilessly fuck, bone and or screw a shady/skanky girl
1) I would definately slay that chick!

2) I slayed the fuck out of that hoocker last night!

3) Slay that bitch!

4) Freddy is off slaying fat bitches...
by karmaster March 19, 2006
769 466
 
2.
killed it. succeeded in something amazing.
Miley's new album slayed
by tsant October 09, 2013
334 80
 
3.
To dip; to use chewing tobacco, also used as a noun to mean dip. commonly used to discretely suggest to another that the two should go to dip in the bathroom. The phrase "Slay all dayyyyy" is used by non dippers to ridicule the dippers because at one time the phrase was quite common in the dipping community and taken seriously. The word is still in use although a few teachers and administrators in the area have discovered the meaning rendering the term un-usable in their presence.
Harrison: hey man lets go slay a grizzly in the bathroom

Riv Dog: Slay all dayyyyyy

Teacher: I know what that means.

Harrison: shit
by IslayGrizzly December 27, 2011
176 110
 
4.
The act of having sexual encounters with someone.
I slayed the hell out of her last night!
by Stainer August 02, 2004
373 318
 
5.
How someone may respond when something outlandish or surprising is said.
"Omgah...that slays me!"
by MelissaDv June 24, 2005
74 37
 
6.
To destroy someone. Mainly cretins.
#SlayTheCretins

or

"Damn what a fucking cretin, SLAY HIM!"

or

"U fkn cunT i slAy u"
by Psych0ticDreams September 01, 2012
92 56
 
7.
To go out drinking and take home a sexual partner.
I'm going to slay Jed tonight, no matter what it takes.
by sailorcharlie June 28, 2012
77 55