When one has an erection for the popular game, Skyrim.
One who struts a Skyrection is likely to fail in every aspect in life, other than in the game Skyrim.
Symptoms of having a Skyrection include game play of Skyrim of 6+ hours daily, sexual arousal towards dragons and Skyrim creatures, obesity, death, loss of education, and/or loss of career.
Person A: Hey, have you seen Jim lately?
Person B: Haven't you heard? He quit his job to support his Skyrection. It's so big it's like he swallowed a whole bottle of Skyagra.
Person A: Damn dude. We better start planning his funeral.