Top Definition
A disease in which the infected has an illogical need to take selfies no matter how ugly or pretty the infected is or how terrible the selfies turn out. Usually, the victim is an ugly, overweight girl, however, these girls can spread it to even the prettiest of girls.
Samantha: Oh. My. God. Look at that girl taking selfies over there!
Hannah: Oh, I know, she's not even pretty, she must Skylar Syndrome.
Samantha: Ew, stay away! I don't want to catch that.
by IdekWhoIAm December 01, 2013

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