Could mean a variety of things, but most importantly it refers to someone who has "Skurped the Durp" and ended up all Skurpty Derpty. One could also "Skurp a Durp" and use either word by itself... i.e. "Durped out", "Skerpt out"
"dude, shit got real weird last night when David went Skurpty Derpty"
"yeah he was super Durped out"