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2.
to fight, or to have a skuffle..
I had a skuff wiv some next man.. he tried cherping my girl
by DJ Hazard - David November 02, 2004
 
1.
Compressed THC marijuana crystal. The finest shit (marijuana) you'll ever find.
Skuff is the king of skunk (shit, marijuana)!
by Blackmegabyte August 24, 2005
 
3.
to lightly hit in a playful manner
I gave him a skuff up side his head.
by pretty little me November 29, 2004