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1.
Compressed THC marijuana crystal. The finest shit (marijuana) you'll ever find.
Skuff is the king of skunk (shit, marijuana)!
by Blackmegabyte August 24, 2005
 
2.
to fight, or to have a skuffle..
I had a skuff wiv some next man.. he tried cherping my girl
by DJ Hazard - David November 02, 2004
 
3.
to lightly hit in a playful manner
I gave him a skuff up side his head.
by pretty little me November 29, 2004