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1.
Schitzophrentic Killing Individual. A.K.A- S.K.I

Crazy Split Personality.
Person who is involved in Illegal acts of violence.
Damn that nigga done went Skizzo.
by Ya Mother March 28, 2006
 
2.
a skank-ass hizzo
by Anonymous July 02, 2003
 
3.
Juggalo slang for nuts
Yo Ninja, off the skizzos!

'Ey homie, that lettes is wycked on my skizzos.
by TrueHatchetRyda July 21, 2009