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1.
A derogatory term describing someone who is adamantly skeptical
"You freaking skepo! It's obviously true"
by Stubz88 September 29, 2008
 
2.
Someone who doubts, questions, or disagrees with what their friends do.
Of course you can't overdose on marijuana. Don't be such a skepo.
by Amarusi June 30, 2009