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1.
It is a term which applies to a male who a female feels is like her sister. It is a term of enderment which signifies a close, nonsexual bond between two unrelated people of the opposite sex. Similar to Broseph.
Thanks for doing my hair, your the best sisen ever.
by Brisban June 05, 2009
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Words related to Sisen:

best buds brah brother sister tight