Top Definition
Similar to "Brother from another Mother"

A term used to describe a good friend that you have known almost your whole life. The word "sister" is used because the friend is extremely close to you to the point that she is almost like your sister--but from a different mother.

AND IT RHYMES!
Whats up my sis from another miss!
by xI iTz TOAST Ix May 01, 2010

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