|1.||Sir Isaac Newton|
The deadliest son-of-a-bitch in space, as defined by an unnamed Gunnery Chief on the Citadel in Mass Effect 2.
Every five seconds the main gun of an Everest-class dreadnought accelerates one to 1.3 percent of light speed. It impacts with the force of a 38-kiloton bomb. That is three times the yield of the city-buster dropped on Hiroshima back on Earth. That means, Sir Isaac Newton was the deadliest son-of-a-bitch in space.