Top Definition
The worst kind of Brian in his altered form. A Sick Brian is like a Bad Luck Brian on steroids. He is a bummer to be around and is also very salty. There are only two cures: horse semen and duck butter.
Person 1. Hey Brian do you want to go to the movies?
Sick Brian. No dude, I'm sick.
Person 2. Man Sick Brian sucks!
by Concerned Roommates October 09, 2013

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