Mikey: For sure, yo! Fo Sho!
Used jokingly: One who is very strange, unattractive, uncouth, and/or trashy, which could possibly be ascribed to birth defects.
Taken from the novel "The Handmaid's Tale" by Margaret Atwood, where a shredder is one who is the defective product of radiation altered reproductive cells.
An acknowledgement of something bad or unfortunate.
Near Synonyms: this sucks, sucks
See examples for proper usage.
Dave: My iPod got stolen last night.
Bill: Aw shredders man, that's not cool!