1) A political campaign slogan encouraging a NO vote on SHIT.
(U down with this shit? / No. Down with shit, man!)
2) The obvious response to someone asking, "No shit?" when you just got through confirming your truth by declaring, "No shit !!"
RAY: "I'm voting NO on SPECIAL RIGHTS for illegal SHIT."
JAY: "Well, I ain't votin' for shit on Tuesday. SHIT NO !!"
GD2: "Blah blah ... bla blah blah. No shit !!"
CPU: "No shit?"
GD2: "SHIT NO !!