Top Definition
A disease that occurs in women wearing huge sunglasses, that deceives everyone into thinking she's hot....until she takes off those big sunglasses and people realize she's ugly. This type of female can usually be spotted on college campuses across the country.
Richard: "Wow, I thought that girl with the big sunglasses was smokin hot, until she took off those sunglasses. She suffers from Shady Syndrome, dammit."

Brandon: "Richard, you can't be picky. Go up and talk to her anyways. You haven't been laid in 3 years.
by Texas Tech Grad June 08, 2009

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