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1.
The feeling that among your group of friends, you are the only normal one.
"My wacky friends are all driving me crazy! If it's not one weird problem, it's another."

"Damn, sounds like hardcore Seinfeld Syndrome."
by Baseball Heavy August 07, 2007
 
2.
When an actor stars in a huge movie or TV role and is never cast for anything else ever again.
Boy 1: Have you ever seen Kramer in any other show?

Boy 2: No, he doesn't have any roles besides playing Kramer. He fell to the Seinfeld syndrome.
by FoxMcWeezer December 13, 2009