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2. Screw up
1. To fail at something, to do something wrong/incorrectly (sometimes repeatedly). Someone that screws up a lot is called a "screw-up"

2. To describe hurting someone emotionally or physically. Commonly used when threatening the one you want to hurt.
1.
Person 1: "I stayed up late last night to study but I couldn't concentrate that well."
Person 2: "You're gonna screw up that test."

"This is the 5th time in a row I'm getting a bad grade. I'm really screwing up."

"I couldn't stop stuttering when introducing myself to him. I screwed up so badly."

2.
"Oh yeah!? You wanna mess with me, kid!? Ohh, I'm gonna SCREW YOU UP!"

Person 1: "Haha, I totally screwed that kid up, did you see his black eye?"
Person 2: "Yeah, he deserved it!"
1. screw up
someone who messes up consistently
Your failing, Jimmy?! I swear it, you're gettin to be a screw up.
by Nicole Feb 16, 2004 add a video
3. screw up
Screw up is when you say the wrong name to your bitch while having sex.
uhhh Britney spears, you're so hot - SLAP - My name is Celine dion you stupid motherfucker!
by Kasper Nielsen Apr 3, 2004 add a video
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