Top Definition
An exaggeration stemming from the term 'Fuck me sideways...' and adding the verbal irony of the words 'screw' and 'nail' as references to sex. Used as an exclamation in response of surprise, anger, etc.
"You what?! Well screw me sideways with a nail gun..."

"Screw me sideways with a nail gun... I got another ticket..."

"Screw me sideways with a nail gun! That freaking hurt!"

by Korana Constantine November 16, 2008
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