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1.
When a girl gives a guy a blow job repeatedly and the guy eats her out. It must all happen in the same night and the guy must be older. Usually done when sex is wanted but impossible due to lack of a condom.
Friend 1: Hey did you and Sally go all the way last night?
Friend 2: Nah, we wanted to but didn't have protection, so instead we santangeloed.
by Because your a whore March 03, 2010
 
2.
The art of disguising personal insecurities with humor and personal attacks on others.
Feeling inferior in the company of such great men, Andy pulled a Santangelo by bringing up Mike's recent visit to his family doctor.
by MDV April 25, 2006