Top Definition
An act of greeting wherein one person grabs the other person's crotch as opposed to their hand. Generally, this act is done between two people of the same gender. This act is especially prevalent in college frat houses and from people named Bryce.
Bryce greeted me with a San Francisco handshake after driving twelve hours to see me.

After several beers, Mark asked the girls at the bar for a San Francisco handshake. They all declined.
by The_BFD February 10, 2013
When 2 guys sit across from each other and give each other hand jobs.
Nick: Where are Jon and Jose?
Mike: Probably in Jose's basement doing a San Francisco Handshake.
by MilMike15 July 10, 2008
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