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1.
Natives of South Africa (mainly used in the UK).
Based on the abbreviation for South Africa as SAf.
Come to our BBQ, there will be lots of Ozzies, Kiwis and Saffers there!
by Mike O'Donnell October 18, 2007
 
2.
South African. Originates from the way some Londoners pronounce "Saff Africa". (Mainly used in England, esp. London)
There are enough southern hemisphere rugby players in the Guinness Premiership to make a team of only Saffers, Kiwis and Aussies!
by totiboy January 13, 2010
 
3.
commonly know in the medical marijuana industry as a word for suffer.
I saffer from back pain.
by flj27 April 12, 2011