1. An area north of Fuschia City in the original Pokemon games where strapping young lads wandered in search of some of the rarest Pokemon in all of Johto.
2. More commonly used to refer to a bar, or other place, where horny men go to pick up drunk sluts.
Adrian: "I'm going all Safari Zone, y'all try to roll?"
Thomas: "No... I don't have any confidence in myself."
Adrian: "What's the deal?"
Thomas: "Dude, I just have this really tiny penis."
Adrian: "Yeah shit mane, can't try to roll with no four-inch chode tryin' to do none... Out, negro."