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1.
Shut Up or Fuck Off
Nat I've been telling you for 10 days now I wont give you my Apad as much as you want it so just SUFO.
by ZODIAC August 19, 2010
 
2.
Abbriviation for "Shut up for one second". Use it during conversations when people just get very annoying or just won't shut up for one second. Online and IRL.
PersonA: And then I went .... And then I bough.... And then I saw .... And then --

PersonB: SUFOS! You are so annoying!
by Olesya July 05, 2005