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3.
SPU
Short for “Sound Processing Unit” – sound card.
I just bought my new Creative SPU and mounted it in my PC.
by Faalagorn February 15, 2008
 
1.
SPU
Origin: Internet / Instant Messaging

Variation of the word "SUP". Meaning "Whats Up?"

Typing fast and frequent mispellings lead to this more lively version of "SUP"
Bob: Spu!
John: Hey!
by Grizzly October 06, 2004
 
2.
spu
the emission of jizz, cum or sperm; to emit an organic fluid known as semen that usually contains spermatozoa; The process of discharge called ejaculation.
I'm gonna spu my load all over that hottie.
by candygirl69 October 20, 2010
 
4.
SPU
Small Penises United!!!
Nate and Jake are apart of SPU
by Smallpenis1.5 March 11, 2010